GK4P

Across TCGA pan-cancer cohorts, GK4P RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GK4P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GK4P RNA is repressed in tumor relative to normal tissue. In most cancer types GK4P is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where GK4P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GK4P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.258	<.001	9	view →
KIRC	Male	All	−0.681	<.001	7	view →
KIRP	All	All	−0.703	<.001	6	view →
BRCA	Female	All	+0.364	<.001	6	view →
LUSC	Male	II,III,IV	−0.591	<.001	5	view →
KICH	Female	All	−0.648	.025	4	view →
HNSC	Female	III,IV	−0.568	.033	4	view →
COAD	Female	All	−0.495	.004	4	view →
READ	All	III,IV	+0.430	.007	2	view →
STAD	Female	All	+0.311	.018	2	view →
BLCA	Male	III,IV	+0.472	.010	1	view →
ESCA	All	All	+0.333	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GK4P–THCA

Open the THCA breakdown →