Across TCGA patient cohorts, GK2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GK2-associated genes across cancer lineages are JNK_pT183_Y185, TIGAR, and ASNS. Each is linked with GK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GK2-to-partner and partner-to-GK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK2→partner) and Y-score (partner→GK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.119	-1.584	.029	.034	3	2
UCEC	TIGAR →	+0.156	+1.742	.001	.002	3	2
UCEC	ASNS →	+0.337	+1.584	.004	.034	3	2
UCEC	C-Raf →	+0.125	+1.459	.007	.012	3	2
SKCM	TAZ →	+0.169	+1.292	<.001	.032	3	2
UCEC	eIF4E →	+0.186	+2.321	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

GK2 survival (RNA) · tumor vs normal (RNA) · all GK2 data types