Across TCGA cell cohorts, GK2 RNA expression is significantly associated with the mutation status of many other genes, with 181 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GK2-associated genes across cancer lineages are WIZ, NYAP1, and TOP2B. Each is linked with GK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GK2-to-partner and partner-to-GK2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK2→partner) and Y-score (partner→GK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WIZ →	+2.428	+0.426	.007	.006	3	3
PANCREAS	NYAP1 →	+5.139	+0.063	<.001	<.001	3	2
BONE	TOP2B →	+5.169	+0.033	.004	<.001	3	2
OVARY	ANKRD40 →	+4.222	+0.004	.006	<.001	3	2
CNS	ELAVL2 →	+4.169	+0.007	.008	<.001	3	2
CNS	RYBP →	+4.169	+0.007	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

Exploration

GK2 survival (RNA) · tumor vs normal (RNA) · all GK2 data types