Across TCGA cell cohorts, GK2 mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GK2-associated genes across cancer lineages are HELT, TPRX1, and FAM25G. Each is linked with GK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GK2-to-partner and partner-to-GK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK2→partner) and Y-score (partner→GK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.041	+5.321	<.001	.005	3	2
LUNG_NSCLC_LUAD	TPRX1 →	+0.012	+4.536	<.001	<.001	3	2
SKIN	FAM25G →	+0.517	+4.217	<.001	.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.508	+3.212	.005	.006	3	1
LARGE_INTESTINE	SEPSECS →	+0.715	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TTK →	+0.561	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

Exploration

GK2 survival (RNA) · tumor vs normal (RNA) · all GK2 data types