GJD4

Across TCGA patient cohorts, GJD4 mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJD4-associated genes across cancer lineages are HMOX1, NCKAP1L, and IRF8. Each is linked with GJD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJD4-to-partner and partner-to-GJD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMOX1 grouped by GJD4-low versus GJD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJD4→partner) and Y-score (partner→GJD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMOX1 →	+0.804	+3.470	.009	.003	3	2
UCEC	NCKAP1L →	+0.757	+3.459	.005	.005	3	2
UCEC	IRF8 →	+0.963	+3.459	.001	.005	3	2
COAD	CLEC12A →	+0.608	+3.210	.008	.009	3	2
COAD	H3P16 →	+1.697	+3.222	<.001	.008	3	2
UCEC	FPR3 →	+1.080	+3.513	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

HMOX1 by GJD4 expression — UCEC

Explore this box plot interactively →