GJD2

Across TCGA patient cohorts, GJD2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJD2-associated genes across cancer lineages are ATM, Dvl3, and A-Raf_pS299. Each is linked with GJD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJD2-to-partner and partner-to-GJD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GJD2-low versus GJD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJD2→partner) and Y-score (partner→GJD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.409	-3.000	.039	.036	3	2
UCEC	Dvl3 →	+0.161	+2.115	.045	.019	3	2
UCEC	A-Raf_pS299 →	-0.164	-2.584	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.178	-2.102	.015	.019	3	1
UCEC	Ku80 →	+0.228	+2.820	.027	.035	3	1
UCEC	MSH2 →	-0.267	-2.973	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by GJD2 expression — UCEC

Explore this box plot interactively →