GJD2

Across TCGA cell cohorts, GJD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 401 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GJD2-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, Clearance of foreign intracellular nucleic acids, and Response to zinc ion. Each is linked with GJD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GJD2-to-partner and partner-to-GJD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by GJD2-low versus GJD2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJD2→partner) and Y-score (partner→GJD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA splicing, via transesterification reactions →	+0.049	+0.950	<.001	.001	3	4
LUNG_SCLC	Clearance of foreign intracellular nucleic acids →	-1.027	-1.043	<.001	<.001	3	3
LUNG_SCLC	Response to zinc ion →	-0.105	-1.128	.004	.006	2	4
LUNG_SCLC	Skeletal myofibril assembly →	-0.818	-1.514	.001	<.001	3	3
LUNG_SCLC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.050	+0.950	<.001	.001	3	3
LUNG_SCLC	mRNA splicing, via spliceosome →	+0.050	+0.950	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

RNA splicing, via transesterification reactions by GJD2 expression — LUNG_SCLC

Explore this box plot interactively →