GJD2

Across TCGA cell cohorts, GJD2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GJD2-associated genes across cancer lineages are VCY1B, POTED, and TEX36. Each is linked with GJD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJD2-to-partner and partner-to-GJD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by GJD2-low versus GJD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJD2→partner) and Y-score (partner→GJD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VCY1B →	+0.693	+2.936	.001	.007	3	1
LARGE_INTESTINE	POTED →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TEX36 →	+0.087	+2.878	<.001	.009	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.013	+3.562	<.001	.002	3	1
LARGE_INTESTINE	SPDYE4 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.062	+2.994	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

VCY1B by GJD2 expression — LARGE_INTESTINE

Explore this box plot interactively →