GJC3

Across TCGA pan-cancer cohorts, GJC3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GJC3 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GJC3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GJC3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, KIRP, and KIRC are the cancer types where GJC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.787	0.406	<.001	93	view →
KIRP	DFS	Median	III,IV	0.663	0.229	<.001	79	view →
KIRC	DFS	Median	All	0.901	0.696	<.001	51	view →
BRCA	OS	Quartile	III,IV	0.896	0.743	.009	30	view →
LAML	DFS	Tertile	All	0.698	0.466	.009	30	view →
MESO	OS	Median	IV	0.308	0.847	<.001	21	view →
LUAD	DFS	Median	IV	0.666	0.978	.015	16	view →
COAD	DFS	Quartile	IV	0.662	0.357	.004	16	view →
ACC	DFS	Median	IV	0.472	0.089	.012	14	view →
THCA	DFS	Median	All	0.976	0.910	.004	13	view →
CESC	DFS	Tertile	All	0.645	0.797	.016	12	view →
LIHC	OS	Tertile	III,IV	0.749	0.453	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GJC3–UVM (DFS)

Open the UVM breakdown →