Across TCGA cell cohorts, GJC2 mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GJC2-associated genes across cancer lineages are GZMK, LHCGR, and SPRR1A. Each is linked with GJC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJC2-to-partner and partner-to-GJC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJC2→partner) and Y-score (partner→GJC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GZMK →	+0.406	+3.359	.002	.002	3	1
BLOOD_Leukemia	LHCGR →	+0.077	+2.982	.007	.007	3	1
BLOOD_Leukemia	SPRR1A →	+0.174	+3.786	<.001	.002	3	1
BLOOD_Leukemia	ADIG →	+0.012	+4.247	<.001	.004	3	1
BLOOD_Leukemia	C9orf57 →	+0.100	+3.772	<.001	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.065	+3.364	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

Exploration

GJC2 survival (RNA) · tumor vs normal (RNA) · all GJC2 data types