GJC1

Across TCGA patient cohorts, GJC1 mutation is significantly associated with the RNA expression of many other genes, with 2,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJC1-associated genes across cancer lineages are RNU6-83P, FAM219B, and AP4E1. Each is linked with GJC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJC1-to-partner and partner-to-GJC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-83P grouped by GJC1-low versus GJC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJC1→partner) and Y-score (partner→GJC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-83P →	+0.132	+4.186	<.001	.007	3	3
UCEC	FAM219B →	+0.445	+2.087	.003	.006	3	3
UCEC	AP4E1 →	+0.558	+3.312	<.001	<.001	3	3
SKCM	MIR578 →	+0.177	+4.678	<.001	.003	3	2
LUAD	SCGB1D4 →	+0.185	+4.888	<.001	.005	3	2
LUAD	RN7SL553P →	+0.299	+4.631	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,669 associations by consensus.

RNU6-83P by GJC1 expression — SKCM

Explore this box plot interactively →