GJC1

Across TCGA cell cohorts, GJC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,558 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GJC1-associated GO terms across cancer lineages are AV node cell to bundle of His cell communication by electrical coupling, Microtubule cytoskeleton organization involved in mitosis, and Nuclear transport. Each is linked with GJC1 in more than 19 cancer types. Because this analysis shows association rather than direction, both GJC1-to-partner and partner-to-GJC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AV node cell to bundle of His cell communication by electrical coupling grouped by GJC1-low versus GJC1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJC1→partner) and Y-score (partner→GJC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AV node cell to bundle of His cell communication by electrical coupling →	+1.626	+2.247	<.001	<.001	3	20
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.117	+1.357	<.001	<.001	3	17
OESOPHAGUS	Nuclear transport →	+0.101	+2.101	<.001	.004	3	17
OESOPHAGUS	Nucleocytoplasmic transport →	+0.102	+2.101	<.001	.004	3	17
BREAST	Mitotic sister chromatid segregation →	+0.093	+2.145	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.062	+0.744	.003	.006	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,558 associations by consensus.

AV node cell to bundle of His cell communication by electrical coupling by GJC1 expression — OESOPHAGUS

Explore this box plot interactively →