GJC1

Across TCGA cell cohorts, GJC1 mutation is significantly associated with the mutation status of many other genes, with 3,141 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GJC1-associated genes across cancer lineages are KIT, AMBRA1, and CDH18. Each is linked with GJC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GJC1-to-partner and partner-to-GJC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIT grouped by GJC1-low versus GJC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJC1→partner) and Y-score (partner→GJC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIT →	+4.014	+4.969	.008	.008	1	4
BLOOD_Leukemia	AMBRA1 →	+2.870	+3.347	.009	.009	1	4
UPPER_AERODIGESTIVE_TRACT	CDH18 →	+5.392	+5.392	.004	.004	1	4
BLOOD_Lymphoma	PLCL1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	XKR4 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	ADCY8 →	+3.063	+3.498	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,141 associations by consensus.

KIT by GJC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →