GJB7

Across TCGA patient cohorts, GJB7 mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB7-associated genes across cancer lineages are MTCO3P16, RPL30P12, and CKS1BP6. Each is linked with GJB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB7-to-partner and partner-to-GJB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P16 grouped by GJB7-low versus GJB7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB7→partner) and Y-score (partner→GJB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTCO3P16 →	+0.113	+4.308	<.001	.009	3	2
COAD	RPL30P12 →	+0.233	+3.792	<.001	.007	3	2
LUAD	CKS1BP6 →	+0.455	+3.692	<.001	.007	3	2
BLCA	CRYGB →	+0.095	+5.038	.006	.009	3	2
UCEC	TRAJ46 →	+0.276	+3.453	<.001	.003	3	2
UCEC	COX15 →	+0.480	+3.807	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

MTCO3P16 by GJB7 expression — COAD

Explore this box plot interactively →