GJB6

Across TCGA pan-cancer cohorts, GJB6 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GJB6 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GJB6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GJB6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC and GBM are the cancer types where GJB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	1.000	0.889	.036	1	view →
GBM	DFS	Median	All	0.808	0.687	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GJB6–HNSC (DFS)

Open the HNSC breakdown →