GJB6

Across TCGA patient cohorts, GJB6 mutation is significantly associated with the RNA expression of many other genes, with 1,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB6-associated genes across cancer lineages are MRPL49, HIRIP3, and CENPU. Each is linked with GJB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB6-to-partner and partner-to-GJB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49 grouped by GJB6-low versus GJB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB6→partner) and Y-score (partner→GJB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.450	+2.716	.006	.003	3	2
UCEC	HIRIP3 →	+0.452	+3.556	.002	.002	3	2
UCEC	CENPU →	+0.642	+2.202	.003	.001	3	2
UCEC	RAD17 →	+0.404	+2.606	.006	.005	3	2
SKCM	MRPL39 →	+0.476	+2.328	.002	.003	3	2
UCEC	NTAN1 →	+0.519	+3.375	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,603 associations by consensus.

MRPL49 by GJB6 expression — UCEC

Explore this box plot interactively →