GJB6

Across TCGA cell cohorts, GJB6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,861 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible GJB6-associated GO terms across cancer lineages are Gap junction-mediated intercellular transport, Negative regulation of RNA catabolic process, and Negative regulation of mRNA catabolic process. Each is linked with GJB6 in more than 8 cancer types. Because this analysis shows association rather than direction, both GJB6-to-partner and partner-to-GJB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gap junction-mediated intercellular transport grouped by GJB6-low versus GJB6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB6→partner) and Y-score (partner→GJB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Gap junction-mediated intercellular transport →	+1.953	+4.173	<.001	<.001	3	9
PANCREAS	Negative regulation of RNA catabolic process →	+0.051	+1.390	<.001	.007	3	9
BREAST	Negative regulation of mRNA catabolic process →	+0.065	+1.191	<.001	.007	3	8
URINARY_TRACT	Regulation of hair follicle development →	+0.284	+3.494	<.001	<.001	3	8
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.275	+3.280	<.001	.001	3	8
URINARY_TRACT	Desmosome organization →	+0.301	+3.195	.004	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,861 associations by consensus.

Gap junction-mediated intercellular transport by GJB6 expression — URINARY_TRACT

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