Across TCGA patient cohorts, GJB5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,751 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GJB5-associated proteins across cancer lineages are SERPINB5, SFN, and ITGB4. Each is linked with GJB5 in more than 5 cancer types. Because this analysis shows association rather than direction, both GJB5-to-partner and partner-to-GJB5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB5→partner) and Y-score (partner→GJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SERPINB5 →	+1.062	+0.837	.006	.002	2	6
HNSC	SFN →	+0.892	+0.894	<.001	<.001	3	5
LSCC	ITGB4 →	+0.629	+1.663	<.001	<.001	3	5
HNSC	KRT16 →	+1.040	+0.783	<.001	.001	3	5
BRCA	ANXA8L1 →	+1.571	+1.437	<.001	<.001	3	5
COAD	FSCN1 →	+0.631	+2.171	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,751 associations by consensus.

Exploration

GJB5 survival (RNA) · tumor vs normal (RNA) · all GJB5 data types