Across TCGA patient cohorts, GJB5 mutation is significantly associated with the RNA expression of many other genes, with 1,805 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB5-associated genes across cancer lineages are ZDHHC7, VPS26C, and MON1A. Each is linked with GJB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB5-to-partner and partner-to-GJB5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB5→partner) and Y-score (partner→GJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZDHHC7 →	+0.583	+3.724	<.001	<.001	3	2
UCEC	VPS26C →	+0.441	+3.212	.004	.009	3	2
UCEC	MON1A →	+0.674	+4.000	<.001	<.001	3	2
UCEC	PC →	+0.837	+3.721	<.001	<.001	3	2
UCEC	AARS1 →	+0.545	+3.332	.001	.005	3	2
UCEC	VEZF1P1 →	+0.123	+3.111	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,805 associations by consensus.

Exploration

GJB5 survival (RNA) · tumor vs normal (RNA) · all GJB5 data types