Across TCGA cell cohorts, GJB5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,021 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GJB5-associated GO terms across cancer lineages are Cell-substrate junction assembly, Hemidesmosome assembly, and NMDA selective glutamate receptor signaling pathway. Each is linked with GJB5 in more than 10 cancer types. Because this analysis shows association rather than direction, both GJB5-to-partner and partner-to-GJB5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB5→partner) and Y-score (partner→GJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cell-substrate junction assembly →	+0.192	+3.371	<.001	<.001	3	11
OESOPHAGUS	Hemidesmosome assembly →	+0.233	+2.314	.007	.001	3	10
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.265	+2.830	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Positive regulation of iron ion transport →	+1.607	+2.427	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Positive regulation of iron ion transmembrane transport →	+1.607	+2.427	<.001	<.001	3	10
BREAST	Negative regulation of intrinsic apoptotic signaling pathway →	+0.067	+1.755	.002	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,021 associations by consensus.

Exploration

GJB5 survival (RNA) · tumor vs normal (RNA) · all GJB5 data types