Across TCGA cell cohorts, GJB5 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GJB5-associated genes across cancer lineages are ADAD1, OR10V1, and TCERG1L. Each is linked with GJB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB5-to-partner and partner-to-GJB5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB5→partner) and Y-score (partner→GJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAD1 →	+0.097	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OR10V1 →	+0.028	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TCERG1L →	+1.824	+4.066	<.001	.004	3	1
BLOOD_Leukemia	RNF186 →	+0.083	+4.450	<.001	.001	3	1
BLOOD_Leukemia	USP17L13 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	LYZL6 →	+0.015	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

GJB5 survival (RNA) · tumor vs normal (RNA) · all GJB5 data types