Across TCGA patient cohorts, GJB4 RNA expression is significantly associated with the RNA expression of many other genes, with 12,733 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible GJB4-associated genes across cancer lineages are GJB3, GJB5, and LAMB3. Each is linked with GJB4 in more than 29 cancer types. Because this analysis shows association rather than direction, both GJB4-to-partner and partner-to-GJB4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB4→partner) and Y-score (partner→GJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	GJB3 →	+2.319	+1.340	<.001	<.001	3	30
ESCA	GJB5 →	+2.936	+1.719	<.001	<.001	3	30
UCS	LAMB3 →	+2.936	+0.697	<.001	.001	3	23
ESCA	TRIM29 →	+2.612	+1.475	<.001	<.001	3	23
TGCT	PERP →	+2.425	+0.731	<.001	<.001	3	23
PAAD	LAMC2 →	+1.725	+1.306	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,733 associations by consensus.

Exploration

GJB4 survival (RNA) · tumor vs normal (RNA) · all GJB4 data types