Across TCGA patient cohorts, GJB4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GJB4-associated genes across cancer lineages are Annexin-1, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with GJB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both GJB4-to-partner and partner-to-GJB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB4→partner) and Y-score (partner→GJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.665	+2.434	<.001	.001	3	2
COAD	Cyclin-B1 →	+0.561	+3.330	.028	.005	3	2
COAD	Caspase-7-cleavedD198 →	+1.558	+3.330	<.001	.005	1	4
SKCM	P-Cadherin →	+0.319	+3.169	.006	.017	3	2
UCEC	ERK2 →	+0.209	+2.459	.003	.018	3	1
UCEC	GAPDH →	+0.416	+2.321	.034	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

GJB4 survival (RNA) · tumor vs normal (RNA) · all GJB4 data types