Across TCGA cell cohorts, GJB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,042 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GJB4-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and Maintenance of blood-brain barrier. Each is linked with GJB4 in more than 11 cancer types. Because this analysis shows association rather than direction, both GJB4-to-partner and partner-to-GJB4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB4→partner) and Y-score (partner→GJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of iron ion transport →	+1.765	+1.988	<.001	.001	3	12
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.765	+1.988	<.001	.001	3	12
OVARY	Maintenance of blood-brain barrier →	+0.204	+0.853	<.001	.005	3	12
URINARY_TRACT	Cell-substrate junction organization →	+0.164	+1.521	<.001	.002	3	11
URINARY_TRACT	Nail development →	+0.449	+2.190	<.001	<.001	3	11
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.255	+1.662	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,042 associations by consensus.

Exploration

GJB4 survival (RNA) · tumor vs normal (RNA) · all GJB4 data types