Across TCGA patient cohorts, GJB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,029 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GJB3-associated proteins across cancer lineages are SERPINB5, ERO1A, and LAMB3. Each is linked with GJB3 in more than 6 cancer types. Because this analysis shows association rather than direction, both GJB3-to-partner and partner-to-GJB3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB3→partner) and Y-score (partner→GJB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SERPINB5 →	+1.441	+0.900	<.001	<.001	3	7
BRCA	ERO1A →	+0.622	+1.548	<.001	<.001	3	7
PDAC	LAMB3 →	+0.937	+1.119	<.001	<.001	3	6
PDAC	CDA →	+0.605	+0.515	.001	.009	2	7
HNSC	CLIP1 →	+0.272	+0.781	.001	<.001	3	6
HNSC	AHNAK2 →	+0.763	+0.742	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,029 associations by consensus.

Exploration

GJB3 survival (RNA) · tumor vs normal (RNA) · all GJB3 data types