Across TCGA patient cohorts, GJB3 protein abundance is significantly associated with the RNA expression of many other genes, with 956 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GJB3-associated genes across cancer lineages are C16orf74, RCAN2, and B3GALT1-AS1. Each is linked with GJB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB3-to-partner and partner-to-GJB3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB3→partner) and Y-score (partner→GJB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C16orf74 →	+0.978	+1.127	.001	.002	3	2
LSCC	RCAN2 →	-1.071	-1.433	.001	<.001	3	2
HNSC	B3GALT1-AS1 →	-0.492	-0.803	.003	.002	3	2
PDAC	ISM2 →	+0.058	+1.030	.009	.001	3	1
PDAC	MEFV →	+0.521	+1.324	.002	.002	3	1
PDAC	RIPK2 →	+0.521	+1.497	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 956 associations by consensus.

Exploration

GJB3 survival (RNA) · tumor vs normal (RNA) · all GJB3 data types