Across TCGA patient cohorts, GJB3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB3-associated genes across cancer lineages are MEK1, ATM, and CDK1. Each is linked with GJB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB3-to-partner and partner-to-GJB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB3→partner) and Y-score (partner→GJB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.308	+2.321	.041	.006	3	2
UCEC	ATM →	-0.479	-1.807	.010	.027	3	2
UCEC	CDK1 →	+0.160	+2.321	.010	.034	3	2
UCEC	EGFR_pY1068 →	-0.290	-2.584	.005	.010	3	1
UCEC	HER3 →	-0.256	-1.794	.023	.027	3	1
UCEC	IGFBP2 →	-0.850	-3.169	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

GJB3 survival (RNA) · tumor vs normal (RNA) · all GJB3 data types