Across TCGA cell cohorts, GJB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,025 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GJB3-associated GO terms across cancer lineages are Protein localization to cell-cell junction, Positive regulation of iron ion transport, and Positive regulation of iron ion transmembrane transport. Each is linked with GJB3 in more than 12 cancer types. Because this analysis shows association rather than direction, both GJB3-to-partner and partner-to-GJB3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB3→partner) and Y-score (partner→GJB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein localization to cell-cell junction →	+0.201	+4.205	<.001	<.001	3	13
BREAST	Positive regulation of iron ion transport →	+1.655	+3.196	<.001	<.001	3	13
BREAST	Positive regulation of iron ion transmembrane transport →	+1.655	+3.196	<.001	<.001	3	13
PANCREAS	Negative regulation of actin filament polymerization →	+0.167	+1.925	<.001	.003	3	12
BREAST	Negative regulation of defense response →	+0.099	+3.272	<.001	<.001	3	12
STOMACH	Nail development →	+0.582	+2.998	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,025 associations by consensus.

Exploration

GJB3 survival (RNA) · tumor vs normal (RNA) · all GJB3 data types