GJB2

Across TCGA patient cohorts, GJB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,752 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GJB2-associated proteins across cancer lineages are MYO1E, LOX, and PLAU. Each is linked with GJB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both GJB2-to-partner and partner-to-GJB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GJB2 versus MYO1E in OV, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB2→partner) and Y-score (partner→GJB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYO1E →	+0.323	+1.626	<.001	<.001	3	8
OV	LOX →	+0.898	+2.079	<.001	<.001	3	8
GBM	PLAU →	+0.853	+1.853	<.001	<.001	3	8
OV	MMP14 →	+0.573	+2.142	<.001	<.001	3	7
OV	MXRA5 →	+0.897	+2.457	<.001	<.001	3	7
GBM	P3H1 →	+0.654	+1.609	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,752 associations by consensus.

GJB2 vs MYO1E — OV

Explore this scatter interactively →