GJB2

Across TCGA patient cohorts, GJB2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,828 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GJB2-associated genes across cancer lineages are PAQR5, ZNF222, and IFFO2. Each is linked with GJB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB2-to-partner and partner-to-GJB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GJB2 versus PAQR5 in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB2→partner) and Y-score (partner→GJB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PAQR5 →	+0.775	+0.636	<.001	<.001	3	2
HNSC	ZNF222 →	-0.576	-0.735	<.001	<.001	3	2
OV	IFFO2 →	+1.404	+1.416	.002	.006	3	2
OV	CALB2 →	+3.336	+1.422	<.001	.009	3	2
HNSC	RBM34 →	-0.631	-0.835	.002	.001	3	2
OV	COA6-AS1 →	-0.815	-0.981	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,828 associations by consensus.

GJB2 vs PAQR5 — HNSC

Explore this scatter interactively →