GJB1

Across TCGA pan-cancer cohorts, GJB1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GJB1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GJB1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GJB1 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

LIHC, SKCM, and SCLC are the cancer types where GJB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.077	0.543	.002	18	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →
SCLC	OS	Median	IV	0.938	0.260	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GJB1–LIHC (DFS)

Open the LIHC breakdown →