GJB1

Across TCGA pan-cancer cohorts, GJB1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GJB1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GJB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GJB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where GJB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.978	0.397	.018	25	view →
PDAC	OS	Tertile	II,III,IV	0.933	0.735	.014	13	view →
LUAD	OS	Quartile	II,III,IV	0.313	1.000	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GJB1–CCRCC (DFS)

Open the CCRCC breakdown →