GJB1

Across TCGA patient cohorts, GJB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,288 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GJB1-associated proteins across cancer lineages are DDAH1, GJB1_S233, and GJB1_S266. Each is linked with GJB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GJB1 versus DDAH1 in BRCA, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	+0.567	+1.064	<.001	<.001	3	8
OV	GJB1_S233 →	+4.750	+4.510	<.001	.002	3	8
BRCA	GJB1_S266 →	+2.672	+3.797	<.001	<.001	3	8
OV	PLEKHA6 →	+0.555	+1.038	<.001	.002	3	7
LUAD	PBLD →	+0.756	+1.613	<.001	<.001	3	7
OV	ASRGL1 →	+0.817	+1.258	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,288 associations by consensus.

GJB1 vs DDAH1 — BRCA

Explore this scatter interactively →