GJB1

Across TCGA patient cohorts, GJB1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,724 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GJB1-associated genes across cancer lineages are GAL3ST1, ETFBKMT, and XCL2. Each is linked with GJB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GJB1 versus GAL3ST1 in GBM, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GAL3ST1 →	+1.598	+0.838	.006	.002	3	3
LUAD	ETFBKMT →	+0.648	+1.237	<.001	<.001	3	3
COAD	XCL2 →	-0.781	-0.906	.009	.003	3	3
CCRCC	TMEM125 →	+1.177	+0.340	<.001	.005	3	3
OV	PCOLCE →	-1.875	-1.117	.001	.001	3	2
CCRCC	UNC93A →	+1.168	+0.442	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,724 associations by consensus.

GJB1 vs GAL3ST1 — GBM

Explore this scatter interactively →