GJB1

Across TCGA patient cohorts, GJB1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB1-associated genes across cancer lineages are EGFR_pY1173, eEF2, and EGFR_pY1068. Each is linked with GJB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by GJB1-low versus GJB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.078	+2.026	.031	.018	3	2
UCEC	eEF2 →	+0.344	+2.000	.033	.032	3	1
UCEC	EGFR_pY1068 →	-0.290	-3.169	.010	.019	3	1
UCEC	A-Raf_pS299 →	-0.145	-2.999	.006	.035	3	1
UCEC	HER3_pY1289 →	+0.104	+3.189	.007	.010	3	1
UCEC	Ku80 →	+0.363	+3.820	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1173 by GJB1 expression — UCEC

Explore this box plot interactively →