GJB1

Across TCGA cell cohorts, GJB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,136 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GJB1-associated GO terms across cancer lineages are Collagen fibril organization, Regulation of clathrin coat assembly, and Regulation of fibrinolysis. Each is linked with GJB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen fibril organization grouped by GJB1-low versus GJB1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Collagen fibril organization →	-0.243	-0.226	<.001	<.001	3	8
LUNG_SCLC	Regulation of clathrin coat assembly →	+0.171	+2.046	<.001	.008	3	8
SKIN	Regulation of fibrinolysis →	-0.185	-3.049	<.001	<.001	3	8
LIVER	Establishment of apical/basal cell polarity →	-0.156	-3.013	.003	.002	3	8
LUNG_SCLC	Regulation of mesenchymal stem cell proliferation →	-0.152	-2.433	<.001	<.001	3	7
LUNG_SCLC	Positive regulation of mesenchymal stem cell proliferation →	-0.152	-2.433	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,136 associations by consensus.

Collagen fibril organization by GJB1 expression — KIDNEY

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