GJB1

Across TCGA cell cohorts, GJB1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GJB1-associated genes across cancer lineages are TTLL8, DEFA4, and ELOA3DP. Each is linked with GJB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by GJB1-low versus GJB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ELOA3DP →	+0.023	+4.273	.003	.006	3	1
LARGE_INTESTINE	PPIAL4E →	+0.044	+4.095	<.001	.009	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TTLL8 by GJB1 expression — LARGE_INTESTINE

Explore this box plot interactively →