GJA9

Across TCGA patient cohorts, GJA9 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA9-associated genes across cancer lineages are FASN, p38-MAPK_pT180_Y182, and EGFR_pY1068. Each is linked with GJA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA9-to-partner and partner-to-GJA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by GJA9-low versus GJA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA9→partner) and Y-score (partner→GJA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.303	+1.807	.029	.025	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.410	-1.906	.009	.015	3	2
UCEC	EGFR_pY1068 →	-0.216	-2.459	.014	.018	3	1
UCEC	MEK1 →	+0.476	+3.169	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.125	-2.687	.017	.005	3	1
UCEC	Notch1 →	+0.146	+2.472	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FASN by GJA9 expression — UCEC

Explore this box plot interactively →