GJA8

Across TCGA pan-cancer cohorts, GJA8 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated GJA8 data layer compared with 17 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher GJA8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GJA8 expression acts as an unfavorable survival marker.

THCA, STAD, and CESC are the cancer types where GJA8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.032	0.950	<.001	48	view →
STAD	OS	Median	All	0.278	0.678	<.001	36	view →
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	30	view →
BLCA	OS	Median	All	0.069	0.688	<.001	24	view →
COAD	OS	Median	All	0.304	0.636	.003	16	view →
LUAD	DFS	Median	II,III,IV	0.327	0.687	.002	12	view →
LIHC	DFS	Median	II,III,IV	0.094	0.429	.016	9	view →
ESCA	DFS	Median	II,III,IV	0.052	0.523	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	0.369	0.718	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

GJA8–THCA (OS)

Open the THCA breakdown →