GJA5

Across TCGA patient cohorts, GJA5 mutation is significantly associated with the RNA expression of many other genes, with 1,493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA5-associated genes across cancer lineages are HELLS, KIF18A, and NUSAP1. Each is linked with GJA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJA5-to-partner and partner-to-GJA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by GJA5-low versus GJA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA5→partner) and Y-score (partner→GJA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HELLS →	+0.585	+3.364	.005	.004	3	3
UCEC	KIF18A →	+0.620	+3.343	.005	.005	3	3
UCEC	NUSAP1 →	+0.834	+2.939	.001	<.001	3	3
UCEC	KIF11 →	+0.741	+2.457	.004	.001	3	3
UCEC	CCNA2 →	+0.751	+2.732	.004	.003	3	3
UCEC	CDC45 →	+0.801	+2.468	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,493 associations by consensus.

HELLS by GJA5 expression — UCEC

Explore this box plot interactively →