GJA5

Across TCGA cell cohorts, GJA5 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GJA5-associated genes across cancer lineages are OR52E8, OR2T6, and OR2V1. Each is linked with GJA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA5-to-partner and partner-to-GJA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E8 grouped by GJA5-low versus GJA5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA5→partner) and Y-score (partner→GJA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR52E8 →	+0.053	+5.643	<.001	.002	3	1
LUNG_SCLC	OR2T6 →	+0.035	+5.029	<.001	.006	3	1
LARGE_INTESTINE	OR2V1 →	+0.042	+4.095	.004	.009	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	TSGA10IP →	+0.194	+4.145	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ZPBP2 →	+0.531	+2.882	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR52E8 by GJA5 expression — LUNG_SCLC

Explore this box plot interactively →