GJA4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GJA4 mutation is significantly associated with the RNA expression of many other genes, with 2,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA4-associated genes across cancer lineages are MIR425, MIR5088, and MIR8053. Each is linked with GJA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA4-to-partner and partner-to-GJA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA4→partner) and Y-score (partner→GJA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADMIR425 →+1.200+4.022<.001<.00132
COADMIR5088 →+0.264+4.332<.001.00632
COADMIR8053 →+0.241+4.136<.001.00832
READATP6V1E1P2 →+0.442+5.039<.001.00832
LGGCGB1 →+0.064+7.977<.001.00732
UCECUHRF1 →+0.750+3.010.005<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,088 associations by consensus.

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