Across TCGA patient cohorts, GJA4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA4-associated genes across cancer lineages are ASNS, JNK2, and Ku80. Each is linked with GJA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJA4-to-partner and partner-to-GJA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA4→partner) and Y-score (partner→GJA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.426	+2.321	.011	.034	3	3
UCEC	JNK2 →	+0.264	+2.179	.004	.034	3	1
UCEC	Ku80 →	+0.240	+1.887	.029	.031	3	1
UCEC	MEK1 →	+0.476	+3.700	.005	.001	3	1
UCEC	Notch1 →	+0.206	+3.179	.001	.010	3	1
UCEC	p62 Lck ligand →	+0.379	+3.009	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

GJA4 survival (RNA) · tumor vs normal (RNA) · all GJA4 data types