GJA1

Across TCGA pan-cancer cohorts, GJA1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GJA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GJA1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GJA1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where GJA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GJA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.023	<.001	11	view →
CCRCC	Male	III,IV	+0.996	<.001	11	view →
LSCC	Female	All	+0.950	<.001	8	view →
PDAC	All	II,III,IV	+0.847	<.001	6	view →
LUAD	All	All	−0.176	.004	2	view →
COAD	Male	II,III,IV	+0.860	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GJA1–HNSC

Open the HNSC breakdown →