GIT2

Across TCGA patient cohorts, GIT2 mutation is significantly associated with the RNA expression of many other genes, with 3,255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIT2-associated genes across cancer lineages are PIMREG, RN7SL714P, and OIP5. Each is linked with GIT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GIT2-to-partner and partner-to-GIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by GIT2-low versus GIT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIT2→partner) and Y-score (partner→GIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.607	+2.343	.004	<.001	3	3
LIHC	RN7SL714P →	+0.082	+5.914	<.001	<.001	3	2
UCEC	OIP5 →	+0.847	+2.721	<.001	<.001	3	2
UCEC	LEPROTL1 →	+0.422	+4.119	<.001	<.001	3	2
UCEC	KXD1 →	+0.398	+2.354	<.001	<.001	3	2
UCEC	TBC1D13 →	+0.353	+2.321	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,255 associations by consensus.

PIMREG by GIT2 expression — UCEC

Explore this box plot interactively →