GIT2

Across TCGA patient cohorts, GIT2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIT2-associated genes across cancer lineages are INPP4B, ATM, and 4E-BP1. Each is linked with GIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIT2-to-partner and partner-to-GIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GIT2-low versus GIT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIT2→partner) and Y-score (partner→GIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.297	-3.584	.012	.002	3	2
UCEC	ATM →	-0.464	-1.847	.005	.008	3	2
UCEC	4E-BP1 →	+0.212	+2.321	.033	.033	3	2
UCEC	14-3-3_beta →	-0.097	-2.432	.008	.018	3	1
UCEC	EGFR →	-0.160	-2.459	.006	.019	3	1
UCEC	A-Raf_pS299 →	-0.142	-2.321	.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

INPP4B by GIT2 expression — UCEC

Explore this box plot interactively →