GIT1

Across TCGA patient cohorts, GIT1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIT1-associated genes across cancer lineages are 4E-BP1, mTOR_pS2448, and Notch1. Each is linked with GIT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GIT1-to-partner and partner-to-GIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GIT1-low versus GIT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIT1→partner) and Y-score (partner→GIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.386	+3.321	<.001	.009	3	3
UCEC	mTOR_pS2448 →	-0.155	-3.156	.009	.018	3	2
UCEC	Notch1 →	+0.136	+3.335	.016	.005	3	2
UCEC	Src_pY527 →	-0.366	-3.311	.034	.010	2	3
UCEC	A-Raf_pS299 →	-0.115	-2.321	.017	.034	3	1
UCEC	Fibronectin →	-0.270	-1.990	.041	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

4E-BP1 by GIT1 expression — UCEC

Explore this box plot interactively →