GIPR

Across TCGA patient cohorts, GIPR mutation is significantly associated with the RNA expression of many other genes, with 707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIPR-associated genes across cancer lineages are TRAJ12, OR5M14P, and PPP3R2. Each is linked with GIPR in more than 1 cancer types. Because this analysis shows association rather than direction, both GIPR-to-partner and partner-to-GIPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by GIPR-low versus GIPR-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPR→partner) and Y-score (partner→GIPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRAJ12 →	+0.834	+4.193	<.001	.009	3	2
CESC	OR5M14P →	+0.098	+4.539	<.001	.008	3	2
SKCM	PPP3R2 →	+0.077	+3.113	<.001	.007	3	2
SKCM	SNORD116-16 →	+0.576	+3.015	<.001	.009	3	2
SKCM	IL5 →	+0.079	+3.468	.002	.008	3	1
CESC	RNU6-626P →	+0.396	+4.669	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

TRAJ12 by GIPR expression — CESC

Explore this box plot interactively →