GIPR

Across TCGA cell cohorts, GIPR mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIPR-associated genes across cancer lineages are WFDC11, DRD3, and CD300H. Each is linked with GIPR in more than 1 cancer types. Because this analysis shows association rather than direction, both GIPR-to-partner and partner-to-GIPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC11 grouped by GIPR-low versus GIPR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPR→partner) and Y-score (partner→GIPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC11 →	+0.038	+4.539	<.001	.007	3	1
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

WFDC11 by GIPR expression — BLOOD_Leukemia

Explore this box plot interactively →