GIPC3

Across TCGA patient cohorts, GIPC3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIPC3-associated genes across cancer lineages are ERK2, GAPDH, and HER2_pY1248. Each is linked with GIPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIPC3-to-partner and partner-to-GIPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GIPC3-low versus GIPC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPC3→partner) and Y-score (partner→GIPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.194	+1.643	.001	.003	3	2
UCEC	GAPDH →	+0.606	+2.247	<.001	.001	3	2
UCEC	HER2_pY1248 →	-0.194	-2.169	.019	<.001	3	2
UCEC	mTOR_pS2448 →	-0.144	-2.156	.001	.002	3	2
UCEC	PDCD4 →	-0.574	-2.060	<.001	.001	3	2
UCEC	VHL →	-0.819	-1.999	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ERK2 by GIPC3 expression — UCEC

Explore this box plot interactively →